3-Amino-5-fluorobenzotrifluoride → HCID 59145682, compound

HRID 517211Notes

Reaction equation

HRID 517211 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([NH2:11])=[O:10])=[CH:4][C:3]=1[C:12]([F:15])([F:14])[F:13].[F:16]C1C=C(C(F)(F)F)C=C(C=1)N>>[F:16][C:7]1[CH:6]=[C:5]([NH:8][C:9]([NH2:11])=[O:10])[CH:4]=[C:3]([C:12]([F:15])([F:14])[F:13])[CH:2]=1

Participants

3

Reactant 2

HCID 27359133-Amino-5-fluorobenzotrifluorideHCID 58266265HCID 58266265, compound2×

Product 1

HCID 59145682HCID 59145682, compound

Procedure

The title compound is prepared in analogy to 1-(4-fluoro-3-(trifluoromethyl)phenyl)urea (intermediate 42), using 5-fluoro-3-(trifluoromethyl)aniline (1.00 g, 5.58 mmol) as starting material. Yield: 630 mg; ESI mass spectrum [M+H]+=223; Retention time HPLC: 0.91 min (Z018_S04).

Workup

  1. custom0.91 min (Z018_S04)

Sources & evidence

ORD record
ord-cf596e6230224507b13ba39804ed924a
Source dataset
uspto-grants-2015_08
Patent number
US09115093B2

Reaction notes

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