反应详情

Formic acid (4.1 mL, 109 mmol) is added to a mixture of tert-butyl carbamate (2.00 g, 17.1 mmol), 4-formyl-3-(methylsulfonyl)benzonitrile (3.57 g, 17.1 mmol) and sodium benzenesulfinate (2.80 g, 17.1 mmol) in a mixture of tetrahydrofuran (12 mL) and water (48 mL), and the mixture is stirred at room temperature for 5 days. Water (60 mL) is added, and the precipitated is filtered, washed with water and dried. Yield: 5.00 g.

1. filtrationthe precipitated is filtered
2. washwashed with water
3. customdried