HCID 86732371, compound → HCID 86732372, compound

HRID 517251Notes

Reaction equation

[C:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[C:18]3[C:17](=[O:19])[CH2:16][CH2:15][CH2:14][C:13]=3[N:12]([C:20]3[CH:25]=[CH:24][CH:23]=[C:22]([C:26]([F:29])([F:28])[F:27])[CH:21]=3)[C:11](=[O:30])[N:10]2[CH2:31][C:32]([OH:34])=[O:33])=[CH:5][CH:4]=1)#[N:2].C(C1C=CC([C@@H]2C3C(=O)CCCC=3N(C3C=CC=C(C(F)(F)F)C=3)C(=O)N2CC(OC)=O)=CC=1)#N>>[C:1]([C:3]1[CH:4]=[CH:5][C:6]([C@@H:9]2[C:18]3[C:17](=[O:19])[CH2:16][CH2:15][CH2:14][C:13]=3[N:12]([C:20]3[CH:25]=[CH:24][CH:23]=[C:22]([C:26]([F:28])([F:29])[F:27])[CH:21]=3)[C:11](=[O:30])[N:10]2[CH2:31][C:32]([OH:34])=[O:33])=[CH:7][CH:8]=1)#[N:2]

Participants

Reactant 2

HCID 86732371HCID 86732371, compound

HCID 86732373HCID 86732373, compound

Product 1

HCID 86732372HCID 86732372, compound

Procedure

The title compound is prepared in analogy to 2-(4-(4-cyanophenyl)-2,5-dioxo-1-(3-(tri-fluoromethyl)phenyl)-1,2,5,6,7,8-hexahydroquinazolin-3(4H)-yl)acetic acid (example 32), using (R)-methyl 2-(4-(4-cyanophenyl)-2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-1,2,5,6,7,8-hexahydroquinazolin-3(4H)-yl)acetate (example 31A, 30 mg, 62 μmol) as starting material. Yield: 27 mg; ESI mass spectrum [M+H]+=470; Retention time: 1.09 min (V001—006).

Sources & evidence

ORD record: ord-100f16e7522f411a9767d9071b4dd0c4
Source dataset: uspto-grants-2015_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09115093B2

Reaction notes

Loading…