Lithium Hydroxide → HCID 86732384, compound

HRID 517261Notes

Reaction equation

HRID 517261 reaction equation
[OH-].[Li+].[C:3]([C:5]1[CH:10]=[CH:9][C:8]([CH:11]2[C:20]3[C:19](=[O:21])[CH2:18][CH2:17][CH2:16][C:15]=3[N:14]([C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([C:28]([F:31])([F:30])[F:29])[CH:23]=3)[C:13](=[O:32])[N:12]2[S:33]([CH2:36][CH2:37][CH2:38][C:39]([O:41]C)=[O:40])(=[O:35])=[O:34])=[CH:7][CH:6]=1)#[N:4]>O.O1CCOCC1>[C:3]([C:5]1[CH:10]=[CH:9][C:8]([CH:11]2[C:20]3[C:19](=[O:21])[CH2:18][CH2:17][CH2:16][C:15]=3[N:14]([C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([C:28]([F:30])([F:29])[F:31])[CH:23]=3)[C:13](=[O:32])[N:12]2[S:33]([CH2:36][CH2:37][CH2:38][C:39]([OH:41])=[O:40])(=[O:34])=[O:35])=[CH:7][CH:6]=1)#[N:4]

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 86732385HCID 86732385, compound

Product 1

HCID 86732384HCID 86732384, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 312751,4-DioxaneSolvent

Procedure

A solution of lithium hydroxide (2 mg, 84 μmol) in water (200 mL) is added to a solution of methyl 4-(4-(4-cyanophenyl)-2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-1,2,5,6,7,8-hexahydroquinazolin-3(4H)-ylsulfonyl)butanoate (example 44.10, 19 mg, 33 μmol) in 1,4-dioxane (1 mL). The mixture is stirred at room temperature for 2 h and purified by it) preparative HPLC (Waters SunFire™-C18, gradient of acetonitrile in water, 0.1% TFA). Yield: 6 mg; ESI mass spectrum [M+H]+=562; Retention time HPLC: 0.91 min (Z018_S04).

Workup

  1. custompurified by it) preparative HPLC (Waters SunFire™-C18, gradient of acetonitrile in water, 0.1% TFA)
  2. custom0.91 min (Z018_S04)

Sources & evidence

ORD record
ord-43fc33f26bcd49e093bf77077030be5f
Source dataset
uspto-grants-2015_08
Patent number
US09115093B2

Reaction notes

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