3-Amino-1-propanol → HCID 86003215, compound

HRID 517326Notes

Reaction equation

HRID 517326 reaction equation
[OH:1][CH2:2][CH2:3][CH2:4][NH2:5].O([Si:14]([CH:21]([CH3:23])[CH3:22])([CH:18]([CH3:20])[CH3:19])[CH:15]([CH3:17])[CH3:16])S(C(F)(F)F)(=O)=O>ClCCl>[CH:15]([Si:14]([CH:21]([CH3:23])[CH3:22])([CH:18]([CH3:20])[CH3:19])[O:1][CH2:2][CH2:3][CH2:4][NH2:5])([CH3:17])[CH3:16]

Participants

4

Reactant 2

HCID 90863-Amino-1-propanolHCID 2724529Triisopropylsilyl trifluoromethanesulfonate

Product 1

HCID 86003215HCID 86003215, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3-Hydroxylpropylamine (100 μL, 1.31 mmol) was dissolved in dichloromethane (4.4 mL), and triisopropylsilyl triflate (371 μL, 1.38 mmol) was added dropwise at room temperature. After stirring at room temperature for 15 minutes, the mixture was worked up according to a conventional method to give the title compound as a crude product.

Sources & evidence

ORD record
ord-96f709b8f1be48df807beb0289bd0709
Source dataset
uspto-grants-2015_08
Patent number
US09115107B2

Reaction notes

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