Trifluoroacetic acid → (2E)-3-[5-(4-amidinophenoxycarbonyl)-thiophen-2-yl]-2-methylpropenoic acid trifluoroacetic acid salt

HRID 517330Notes

Reaction equation

HRID 517330 reaction equation
C([O:5][C:6](=[O:27])[C:7]([CH3:26])=[CH:8][C:9]1[S:10][C:11]([C:14]([O:16][C:17]2[CH:22]=[CH:21][C:20]([C:23](=[NH:25])[NH2:24])=[CH:19][CH:18]=2)=[O:15])=[CH:12][CH:13]=1)(C)(C)C.[F:28][C:29]([F:34])([F:33])[C:30]([OH:32])=[O:31]>>[F:28][C:29]([F:34])([F:33])[C:30]([OH:32])=[O:31].[C:23]([C:20]1[CH:21]=[CH:22][C:17]([O:16][C:14]([C:11]2[S:10][C:9](/[CH:8]=[C:7](\[CH3:26])/[C:6]([OH:27])=[O:5])=[CH:13][CH:12]=2)=[O:15])=[CH:18][CH:19]=1)(=[NH:24])[NH2:25]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 866733173-[5-(4-Amidinophenoxycarbonyl)thiophen-2-yl]-2-methylpropenoic acid tert-butyl ester

Product 1

HCID 86673318(2E)-3-[5-(4-amidinophenoxycarbonyl)-thiophen-2-yl]-2-methylpropenoic acid trifluoroacetic acid salt

Procedure

To 3-[5-(4-amidinophenoxycarbonyl)thiophen-2-yl]-2-methylpropenoic acid tert-butyl ester (0.63 g) was added trifluoroacetic acid (5 mL), and the mixture was stirred for 30 minutes. The solvent was evaporated to give the title compound (0.62 g).

Workup

  1. customThe solvent was evaporated

Sources & evidence

ORD record
ord-fab8d4dd4b1a47068efab2683897dce6
Source dataset
uspto-grants-2015_08
Patent number
US09115107B2

Reaction notes

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