Urea → 8-Bromoquinazoline-2,4(1H,3H)-dione
Reaction equation
[NH2:1][C:2]1[C:10]([Br:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].[NH2:12][C:13](N)=[O:14]>O>[Br:11][C:10]1[CH:9]=[CH:8][CH:7]=[C:3]2[C:2]=1[NH:1][C:13](=[O:14])[NH:12][C:4]2=[O:5]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 195 °C
Procedure
To a 100 mL round bottom flask, 2-amino-3-bromo-benzoic acid (5 g, 0.0234 mol) and urea (7.33 g, 0.122 mol) were added. The reaction mixture was stirred at 195° C. for 3 h. The reaction mixture was allowed to reach 80° C. and water was added. The aqueous reaction mixture was stirred for 5-10 min and filtered to afford the title compound [5.4 g, 97%]. This material was taken to the next step without any further purification.
Workup
- customto reach 80° C.
- stirringThe aqueous reaction mixture was stirred for 5-10 min
- filtrationfiltered
Sources & evidence
- ORD record
- ord-82a2a7f5693b4afeaa310e8bdd9553fa
- Source dataset
- uspto-grants-2015_08
- Patent number
- US09115092B2
Reaction notes
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