反应详情

A solution of 5 g of 2,4-dichloro-6-methoxy-1,3,5-triazine in 50 ml of acetonitrile is cooled on an ice bath, 3.55 ml of DIPEA and then 5.13 g of 2-[4-(trifluoromethoxy)phenyl]ethanamine are added and the mixture is stirred for 30 minutes. The reaction mixture is partially concentrated under vacuum, an EtOAc/water mixture is added, the phases are separated by settling, the organic phase is washed with saturated NaCl solution and dried over MgSO4, and the solvent is evaporated off under vacuum. The precipitate formed during the evaporation is drained by suction, washed with EtOAc and dried. 7.89 g of the expected compound are obtained.

1. concentrationThe reaction mixture is partially concentrated under vacuum
2. additionan EtOAc/water mixture is added
3. customthe phases are separated
4. washthe organic phase is washed with saturated NaCl solution
5. dry with materialdried over MgSO4
6. customthe solvent is evaporated off under vacuum
7. customThe precipitate formed during the evaporation
8. washwashed with EtOAc
9. customdried