1-(Bromomethyl)naphthalene → Methyl (S)-2-(4-methanesulphonylpiperazin-1-yl)-3-[4-(naphthalen-1-ylmethoxy)benzoylamino]propanoate

Participants

Reaction Steps

In a manner similar to example 4-5, starting from 300 mg (0.8 mmol) of methyl (S)-3-(4-hydroxybenzoylamino)-2-(4-methanesulphonylpiperazin-1-yl)-propanoate (prepared as described in example 4-4) and from 200 mg (1.2 mmol) of 1-bromomethylnaphthalene, 320 mg (78%) of methyl (S)-2-(4-methanesulphonylpiperazin-1-yl)-3-[4-(2-methylquinolin-4-ylmethoxy)benzoylamino]-propanoate are obtained in the form of a white solid.

Provenance & Evidence