HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-(3-Bromobenzyl)-5-methylthiazole-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Lithium hydroxide, monohydrate | HCID 168937 | — |
| Reactant | Ethyl 4-(3-bromobenzyl)-5-methylthiazole-2-carboxylate | HCID 86711493 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Solvent | Methanol tetrahydrofuran water | HCID 21892291 | — |
| Product | 4-(3-Bromobenzyl)-5-methylthiazole-2-carboxylic acid | HCID 86711494 | — |
Reaction Steps
A solution of ethyl 4-(3-bromobenzyl)-5-methylthiazole-2-carboxylate (20 mg, 0.06 mmol) was treated with LiOH.H2O (7.5 mg, 0.18 mmol) in 2 mL of THF/MeOH/H2O (2:1:1) and stirred at RT for 2 h. The reaction was diluted with EtOAc and H2O and then acidified by 6N HCl. The organic layer was separated and concentrated to give a crude which was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09115120B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-1bcc059b980245e1a5ec5e309f855f0a |
| Source note | uspto-grants-2015_08 |