HRID517583

反应详情

EQUATION

反应方程式

REACTANTS

反应物

$结构：CCOc1ccc(/C=C2\SC(=O)NC2=O)cc1$

HCID5878179

未命名化合物

$结构：CCOc1ccc(/C=C2\SC(=O)N(CCCNC(=O)OC(C)(C)C)C2=O)cc1$

HCID71697170

未命名化合物

结构：CC(C)(C)OC(=O)NCC(Br)CNC(=O)OC(C)(C)C

HCID86724396

未命名化合物

PRODUCTS

生成物

$结构：CCOc1ccc(/C=C2\SC(=O)N(C(CNC(=O)OC(C)(C)C)CNC(=O)OC(C)(C)C)C2=O)cc1$

HCID86724395

未命名化合物

收率 23.9%

PROCEDURE

实验过程

The title compound 21e was prepared from compound 2 (292 mg, 1.17 mmol) and di-tert-butyl (2-bromopropane-1,3-diyl)dicarbamate (413 mg, 1.17 mg) in a manner similar to that described for 21a. Yield=23.9%, 130 mg.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0a1070ca5ae749c88731f3f5a5ebb805
来源数据集: uspto-grants-2015_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09115122B2
来源说明: uspto-grants-2015_08

反应 SMILES

[CH2:1]([O:3][C:4]1[CH:17]=[CH:16][C:7](/[CH:8]=[C:9]2/[C:10](=[O:15])[NH:11][C:12](=[O:14])[S:13]/2)=[CH:6][CH:5]=1)[CH3:2].Br[CH:19]([CH2:29][NH:30][C:31](=[O:37])[O:32][C:33]([CH3:36])([CH3:35])[CH3:34])[CH2:20][NH:21][C:22](=[O:28])[O:23][C:24]([CH3:27])([CH3:26])[CH3:25].C(OC1C=CC(/C=C2/C(=O)N(CCCNC(=O)OC(C)(C)C)C(=O)S/2)=CC=1)C>>[CH2:1]([O:3][C:4]1[CH:17]=[CH:16][C:7](/[CH:8]=[C:9]2/[C:10](=[O:15])[N:11]([CH:19]([CH2:29][NH:30][C:31](=[O:37])[O:32][C:33]([CH3:36])([CH3:35])[CH3:34])[CH2:20][NH:21][C:22](=[O:28])[O:23][C:24]([CH3:27])([CH3:25])[CH3:26])[C:12](=[O:14])[S:13]/2)=[CH:6][CH:5]=1)[CH3:2]