HRID517594

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID34367

1-(9-Fluorenyl)methyl chloroformate

C15H11ClO2

HCID81531

Diisopropylethylamine

C8H19N

$结构：CCOc1ccc(/C=C2\SC(=O)N(CCN)C2=O)cc1$

HCID1249836

未命名化合物

$结构：CCOc1ccc(/C=C2\SC(=O)N(CCNC(C)=O)C2=O)cc1$

HCID45485995

未命名化合物

PRODUCTS

生成物

$结构：CCOc1ccc(/C=C2\SC(=O)N(CCNC(=O)OCC3c4ccccc4-c4ccccc43)C2=O)cc1$

HCID71697450

未命名化合物

PROCEDURE

实验过程

The title compound 26e was prepared from compound 76 (101 mg, 0.25 mmol), Fmoc chloride (71 mg, 0.28 mmol) and DIPEA (131 μL, 0.75 mmol) in a manner similar to that described for 25a in 96.4% (124 mg) yield as a yellow solid.

WORKUP

后处理

customyield as a yellow solid

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-81c5924af2c640f8aed4c9902a1672ad
来源数据集: uspto-grants-2015_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09115122B2
来源说明: uspto-grants-2015_08

反应 SMILES

[NH2:1][CH2:2][CH2:3][N:4]1[C:8](=[O:9])/[C:7](=[CH:10]/[C:11]2[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH3:19])=[CH:13][CH:12]=2)/[S:6][C:5]1=[O:20].[C:21](Cl)([O:23][CH2:24][CH:25]1[C:37]2[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=2)[C:31]2[C:26]1=[CH:27][CH:28]=[CH:29][CH:30]=2)=[O:22].CCN(C(C)C)C(C)C.C(OC1C=CC(/C=C2/C(=O)N(CCNC(=O)C)C(=O)S/2)=CC=1)C>>[CH2:18]([O:17][C:14]1[CH:15]=[CH:16][C:11](/[CH:10]=[C:7]2/[C:8](=[O:9])[N:4]([CH2:3][CH2:2][NH:1][C:21](=[O:22])[O:23][CH2:24][CH:25]3[C:37]4[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=4[C:31]4[C:26]3=[CH:27][CH:28]=[CH:29][CH:30]=4)[C:5](=[O:20])[S:6]/2)=[CH:12][CH:13]=1)[CH3:19]