Potassium Carbonate → 1-(1-Ethoxycyclopropyl)-4-ethynyl-2-tert-butylbenzene

HRID 51762Notes

Reaction equation

HRID 51762 reaction equation
[CH2:1]([O:3][C:4]1([C:7]2[CH:12]=[CH:11][C:10]([C:13]#[C:14][Si](C)(C)C)=[CH:9][C:8]=2[C:19]([CH3:22])([CH3:21])[CH3:20])[CH2:6][CH2:5]1)[CH3:2].C(=O)([O-])[O-].[K+].[K+]>CO>[CH2:1]([O:3][C:4]1([C:7]2[CH:12]=[CH:11][C:10]([C:13]#[CH:14])=[CH:9][C:8]=2[C:19]([CH3:20])([CH3:22])[CH3:21])[CH2:6][CH2:5]1)[CH3:2]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 22568955[4-(1-Ethoxycyclopropyl)-3-tert-butyl-phenylethynyl]-trimethylsilane2×

Product 1

HCID 225688751-(1-Ethoxycyclopropyl)-4-ethynyl-2-tert-butylbenzene

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Using General Procedure E; [4-(1-ethoxycyclopropyl)-3-tert-butyl-phenylethynyl]-trimethylsilane (Intermediate 111, 215.0 mg, 0.69 mmol) in methanol (10 mL) was treated with potassium carbonate (80.0 mg, 0.58 mmol) and stirred overnight at ambient temperature. The crude alkyne, 169 mg, was used directly in the next reaction.

Sources & evidence

ORD record
ord-afce896669184d5eb922dd239c56300e
Source dataset
uspto-grants-2004_03
Patent number
US06713647B2

Reaction notes

Loading…