HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 6-Methyl-3-(oxazol-2-yl)picolinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 3-Bromo-6-methylpyridine-2-carboxylic acid | HCID 21901493 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 6-Methyl-3-(oxazol-2-yl)picolinic acid | HCID 90405282 | — |
Reaction Steps
To the title compound of step C (56 mg, 0.3 mmol) was added MeOH (0.6 mL) and 2M NaOH(aq) (0.6 mL). After 1 h at rt, 1M HCl(aq) was added. The reaction mixture was concentrated to give the title compound (52 mg) that was used without further purification in subsequent steps. MS (ESI) mass calcd. for C10H8N2O3, 204.2; m/z found 205.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09115117B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-302bb947378746338863e57030955e56 |
| Source note | uspto-grants-2015_08 |