Hydrochloric Acid → 6-Methyl-3-(oxazol-2-yl)picolinic acid

HRID 517677Notes

Reaction equation

HRID 517677 reaction equation
Br[C:2]1[C:3]([C:9]([OH:11])=[O:10])=[N:4][C:5]([CH3:8])=[CH:6][CH:7]=1.[OH-:12].[Na+].Cl>CO>[CH3:8][C:5]1[N:4]=[C:3]([C:9]([OH:11])=[O:10])[C:2]([C:5]2[O:12][CH:2]=[CH:3][N:4]=2)=[CH:7][CH:6]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 219014933-Bromo-6-methylpyridine-2-carboxylic acid

Product 1

HCID 904052826-Methyl-3-(oxazol-2-yl)picolinic acid

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To the title compound of step C (56 mg, 0.3 mmol) was added MeOH (0.6 mL) and 2M NaOH(aq) (0.6 mL). After 1 h at rt, 1M HCl(aq) was added. The reaction mixture was concentrated to give the title compound (52 mg) that was used without further purification in subsequent steps. MS (ESI) mass calcd. for C10H8N2O3, 204.2; m/z found 205.1 [M+H]+.

Workup

  1. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-302bb947378746338863e57030955e56
Source dataset
uspto-grants-2015_08
Patent number
US09115117B2

Reaction notes

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