Trifluoroacetic acid → HCID 90405222, compound

HRID 517687Notes

Reaction equation

HRID 517687 reaction equation
[CH3:1][C@H:2]1[C@H:7]([NH:8][C:9]2[N:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][N:10]=2)[CH2:6][CH2:5][CH2:4][N:3]1C(OC(C)(C)C)=O.C(O)(C(F)(F)F)=O>C(Cl)Cl.C([O-])([O-])=O.[Na+].[Na+]>[CH3:1][C@H:2]1[C@H:7]([NH:8][C:9]2[N:10]=[CH:11][C:12]([C:15]([F:18])([F:16])[F:17])=[CH:13][N:14]=2)[CH2:6][CH2:5][CH2:4][NH:3]1

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 90406290HCID 90406290, compound

Product 1

HCID 90405222HCID 90405222, compoundYield 95.1%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 10340Sodium CarbonateSolvent

Procedure

To the title compound of step A (1.5 g) in DCM (12 mL) was added TFA (4 mL). After 1 h, the reaction was diluted with saturated Na2CO3 (aq) and extracted with DCM. The organic layers were dried (MgSO4) and concentrated to give the title compound (1.03 g) that was used without further purification.

Workup

  1. extractionextracted with DCM
  2. dry with materialThe organic layers were dried (MgSO4)
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-f374c3b240814a3dbca88ddfb71be23a
Source dataset
uspto-grants-2015_08
Patent number
US09115117B2

Reaction notes

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