1-(4-(Trifluoromethyl)phenyl)ethan-1-one → HCID 2805938, compound

HRID 517692Notes

Reaction equation

HRID 517692 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:8]=[CH:7][C:6]([C:9](=[O:11])[CH3:10])=[CH:5][CH:4]=1.CO[CH:16](OC)[N:17]([CH3:19])[CH3:18]>>[CH3:16][N:17]([CH3:19])[CH:18]=[CH:10][C:9]([C:6]1[CH:5]=[CH:4][C:3]([C:2]([F:12])([F:13])[F:1])=[CH:8][CH:7]=1)=[O:11]

Participants

3

Reactant 2

HCID 697311-(4-(Trifluoromethyl)phenyl)ethan-1-oneHCID 78373Dimethylformamide dimethyl acetal

Product 1

HCID 2805938HCID 2805938, compoundYield 49.9%

Procedure

A solution of 1-[4-(trifluoromethyl)phenyl]ethanone (2 g, 10.63 mmol, Sigma-Aldrich) in dimethylformamide-dimethylacetal (5 ml, 37.3 mmol) was heated to 110° C. and stirred for 18 hours. The reaction mixture was cooled to room temperature then diluted with iso-hexanes (20 ml). The resulting precipitate was filtered then washed with a minimum of iso-hexane to yield the title compound as a yellow solid (1.29 g)

Workup

  1. filtrationThe resulting precipitate was filtered
  2. washthen washed with a minimum of iso-hexane

Sources & evidence

ORD record
ord-302ba7b5356d4431a28d678971dfd61f
Source dataset
uspto-grants-2015_08
Patent number
US09115132B2

Reaction notes

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