HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3,3-Dimethyl-1-({1-[3-(trifluoromethyl)phenyl]-1H-tetrazol-5-yl}methyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | 1,1-Dimethylethyl 2,2-dimethyl-4-({1-[3-(trifluoromethyl)phenyl]-1H-tetrazol-5-yl}methyl)-1-piperazinecarboxylate | HCID 86691866 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3,3-Dimethyl-1-({1-[3-(trifluoromethyl)phenyl]-1H-tetrazol-5-yl}methyl)piperazine | HCID 66654385 | — |
Reaction Steps
To a solution of 1,1-dimethylethyl 2,2-dimethyl-4-({1-[3-(trifluoromethyl)phenyl]-1H-tetrazol-5-yl}methyl)-1-piperazinecarboxylate (567 mg, 1.287 mmol, Intermediate 11) in methanol was added 4M hydrogen chloride in 1,4-Dioxane (7 ml, 28.0 mmol). The reaction mixture was stirred at room temperature for 1 hour.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09115132B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-107c5b4d7ba34d2f88d51a6d21c69e42 |
| Source note | uspto-grants-2015_08 |