反应详情

温度

120 °C

To a mixture of 4-[5-(chloromethyl)-1H-tetrazol-1-yl]-2-(trifluoromethyl)benzonitrile (Intermediate 34, 300 mg, 1.04 mmol) and 1,1-dimethylethyl 2,8-diazaspiro[4.5]decane-2-carboxylate (commercially available, for example from J&W Pharmlab, Levittown, USA, 301 mg, 1.25 mmol) in acetonitrile (5 mL) was added triethylamine (0.173 mL, 1.25 mmol). The reaction was heated at 120° C. for 20 min in a microwave reactor. Solvent was removed under vacuum to afford 680 mg of the title compound as a pale yellow solid.

1. customSolvent was removed under vacuum