反应详情

Ammonium hydroxide solution (50 mL) was added to a stirred solution of 5-fluoro-2-(trifluoromethyl)benzonitrile (commercially available, for example from Alfa Aesar, Ward Hill, Mass., USA, 2.0 g, 10.6 mmol) in 1,4-dioxane (10 mL) and the reaction mixture was heated to 130° C. for 20 h under 200 psi pressure in a steel bomb. The reaction mixture was evaporated to dryness, and the residue was diluted with DCM and washed with water. The organic layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure to afford the crude product. This was purified by column chromatography (100-200 mesh silica gel), eluting with 20%-40% EtOAc/petroleum ether, to give the title compound (1.2 g).

1. customThe reaction mixture was evaporated to dryness
2. additionthe residue was diluted with DCM
3. washwashed with water
4. dry with materialThe organic layer was dried over anhydrous Na2SO4
5. concentrationconcentrated under reduced pressure
6. customto afford the crude product
7. customThis was purified by column chromatography (100-200 mesh silica gel)
8. washeluting with 20%-40% EtOAc/petroleum ether