Formaldehyde → HCID 66656142, compound

Participants

Role	Name	HCID	Charge
Reactant	Formaldehyde	HCID 712	—
Reactant	Triethylamine	HCID 8471	—
Reactant	Azidotrimethylsilane	HCID 78378	—
Reactant	4-Isocyanobenzonitrile	HCID 449775	—
Reactant	3,3-Difluoropyrrolidine hydrochloride	HCID 24903482	—
Solvent	Methanol	HCID 887	—
Product	HCID 66656142	HCID 66656142	—

Reaction Steps

To a solution of 3,3-difluoropyrrolidine hydrochloride (129 mg, 0.90 mmol, Sigma-Aldrich) in methanol (2 mL) was added formaldehyde (37% aqueous) (0.067 mL, 0.90 mmol) and triethylamine (0.125 mL, 0.90 mmol). The reaction mixture was shaken at room temperature for 40 minutes. To the reaction mixture was added 4-isocyanobenzonitrile (128 mg, 1.00 mmol) and trimethylsilylazide (0.133 mL, 1.00 mmol). The reaction mixture was shaken at room temperature for a further 18 hours.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09115132B2
Source dataset	uspto-grants-2015_08
ORD ID	ord-d22528158bdf479483d00f2ddbca2858
Source note	uspto-grants-2015_08