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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 517776Generated: October 31, 2026

Hydrochloric Acid → HCID 66654184, compound

https://huagongshe.com/reaction/517776

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
Reactant1,4-DioxaneHCID 31275—
ReactantHCID 55856315HCID 55856315—
SolventMethanolHCID 887—
ProductHCID 66654184HCID 66654184—

Reaction Steps

To a solution of 1,1-dimethylethyl 4-({1-[4-(trifluoromethyl)phenyl]-1H-tetrazol-5-yl}methyl)-1-piperazinecarboxylate (613 mg, 1.486 mmol, Intermediate 15) in methanol was added 4M hydrogen chloride in 1,4-dioxane (10 mL, 40 mmol). The reaction mixture was stirred at room temperature for 1 hour.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09115132B2
Source datasetuspto-grants-2015_08
ORD IDord-d61a075c3e4e4da8bc4db787a6a015b5
Source noteuspto-grants-2015_08