Hydrochloric Acid → HCID 66654184, compound

HRID 517776Notes

Reaction equation

HRID 517776 reaction equation
[F:1][C:2]([F:29])([F:28])[C:3]1[CH:8]=[CH:7][C:6]([N:9]2[C:13]([CH2:14][N:15]3[CH2:20][CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17][CH2:16]3)=[N:12][N:11]=[N:10]2)=[CH:5][CH:4]=1.Cl.O1CCOCC1>CO>[F:29][C:2]([F:1])([F:28])[C:3]1[CH:4]=[CH:5][C:6]([N:9]2[C:13]([CH2:14][N:15]3[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]3)=[N:12][N:11]=[N:10]2)=[CH:7][CH:8]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 55856315HCID 55856315, compound2×

Product 1

HCID 66654184HCID 66654184, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 1,1-dimethylethyl 4-({1-[4-(trifluoromethyl)phenyl]-1H-tetrazol-5-yl}methyl)-1-piperazinecarboxylate (613 mg, 1.486 mmol, Intermediate 15) in methanol was added 4M hydrogen chloride in 1,4-dioxane (10 mL, 40 mmol). The reaction mixture was stirred at room temperature for 1 hour.

Sources & evidence

ORD record
ord-d61a075c3e4e4da8bc4db787a6a015b5
Source dataset
uspto-grants-2015_08
Patent number
US09115132B2

Reaction notes

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