Triethylamine → HCID 66654754, compound

HRID 517778Notes

Reaction equation

Cl[CH2:2][C:3]1[N:7]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=2)[N:6]=[N:5][N:4]=1.[CH2:18]([S:20]([N:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1)(=[O:22])=[O:21])[CH3:19].C(N(CC)CC)C>C(#N)C>[CH2:18]([S:20]([N:23]1[CH2:24][CH2:25][N:26]([CH2:2][C:3]2[N:7]([C:8]3[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=3)[N:6]=[N:5][N:4]=2)[CH2:27][CH2:28]1)(=[O:22])=[O:21])[CH3:19]

Participants

Conditions

Temperature: 120 °C

Procedure

5-(Chloromethyl)-1-[3-(trifluoromethyl)phenyl]-1H-tetrazole (79 mg, 0.301 mmol, commercially available from UkrOrgSynthesis, Kiev, Ukraine) and 1-(ethylsulfonyl)piperazine (53.6 mg, 0.301 mmol, Sigma-Aldrich) were dissolved in acetonitrile (1.5 ml). Triethylamine (0.046 ml, 0.331 mmol) was added, and the mixture was heated in a microwave with stirring at 120° C. for 20 min. The reaction mixture was concentrated in vacuo and the residue purified by high pH MDAP to yield the title compound as a colourless solid (70 mg).

Workup

temperaturethe mixture was heated in a microwave
concentrationThe reaction mixture was concentrated in vacuo
customthe residue purified by high pH

Sources & evidence

ORD record: ord-accb97eefc7a47948688ea9e5021ea19
Source dataset: uspto-grants-2015_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09115132B2

Reaction notes

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