反应详情

tert-Butyl 6-(6-ethoxy-6-oxohex-2-enyl)-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazine-5(6H)-carboxylate (step 3) (88 mg, 0.158 mmol) in EtOH (3 ml) was degassed with N2 and treated with 10% Pd(C) (1.685 mg, 0.016 mmol). The resulting black suspension was stirred at room temperature under an atmosphere of hydrogen for 16 hours. The resulting mixture was filtered through a pre-packed 2.5 g Celite® column eluting with EtOH. The filtrate concentrated under reduced pressure to afford the titled compound as a yellow oil:

1. filtrationThe resulting mixture was filtered through a pre-packed 2.5 g Celite® column
2. washeluting with EtOH
3. concentrationThe filtrate concentrated under reduced pressure