反应详情

7-Ethyl-2,3-di-p-tolylpyrido[2,3-b]pyrazine (2 g, 5.89 mmol) in EtOH (5 ml) was treated with Pd/C (0.2 g) and placed under an atmosphere of hydrogen. After stirring overnight the mixture was treated with a catalytic quantity of NaHCO3 and stirring continued under hydrogen overnight. The mixture was passed through Celite® (filter material) and the solvent was removed under reduced pressure. Purification of the crude product by chromatography on silica eluting with 5% EtOAc in hexane afforded the titled compound;

1. stirringstirring
2. waitcontinued under hydrogen overnight
3. filtrationThe mixture was passed through Celite® (filter material)
4. customthe solvent was removed under reduced pressure
5. customPurification of the crude product by chromatography on silica eluting with 5% EtOAc in hexane