Methyl vinyl sulfone → HCID 53330041, compound

HRID 517962Notes

Reaction equation

HRID 517962 reaction equation
[CH3:1][N:2]1[C:10]2[CH:9]=[C:8]([C:11]3[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH2:19][CH:20]4[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]4)=[C:13]([C:26]([F:29])([F:28])[F:27])[CH:12]=3)[N:7]=[C:6]([C:30]#[N:31])[C:5]=2[N:4]=[N:3]1.[CH3:32][S:33]([CH:36]=[CH2:37])(=[O:35])=[O:34]>C(#N)C>[CH3:1][N:2]1[C:10]2=[CH:9][C:8]([C:11]3[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH2:19][CH:20]4[CH2:21][CH2:22][N:23]([CH2:37][CH2:36][S:33]([CH3:32])(=[O:35])=[O:34])[CH2:24][CH2:25]4)=[C:13]([C:26]([F:29])([F:28])[F:27])[CH:12]=3)=[N:7][C:6]([C:30]#[N:31])=[C:5]2[N:4]=[N:3]1

Participants

4

Reactant 2

HCID 19354Methyl vinyl sulfoneHCID 67294093HCID 67294093, compound

Product 1

HCID 53330041HCID 53330041, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

1-Methyl-6-(4-(2-(piperidin-4-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1H-[1,2,3]-triazolo[4,5-c]pyridine-4-carbonitrile (50 mg) and methylsulfonylethene (0.051 ml) were combined in acetonitrile (3 ml) and the reaction mixture microwaved at 120° C. for 20 minutes. The reaction mixture was concentrated under vacuum and the resulting solid suspended in methanol and filtered off to afford the title compound (43.8 mg).

Workup

  1. customthe reaction mixture microwaved at 120° C. for 20 minutes
  2. concentrationThe reaction mixture was concentrated under vacuum
  3. filtrationfiltered off

Sources & evidence

ORD record
ord-ac8a79b1a4a3459888a635f6ed5bc3cf
Source dataset
uspto-grants-2015_08
Patent number
US09115126B2

Reaction notes

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