反应详情

温度

0 °C

2-(1-(tert-Butoxycarbonyl)azetidin-3-yl)acetic acid (3.91 g) was dissolved in THF (18.17 ml) and cooled to 0° C. Diborane (1M in THF, 54.5 ml) was added dropwise and the reaction stirred for one hour. Water was added dropwise to quench unreacted borane and the mixture diluted with EtOAc (150 mL) and washed with water (100 mL). Organics were dried over sodium sulphate and solvent evaporated under reduced pressure to afford tert-butyl 3-(2-hydroxyethyl)azetidine-1-carboxylate (100% yield) as a clear oil.

1. customto quench unreacted borane
2. additionthe mixture diluted with EtOAc (150 mL)
3. washwashed with water (100 mL)
4. dry with materialOrganics were dried over sodium sulphate and solvent
5. customevaporated under reduced pressure