反应详情

温度

160 °C

1.4 g (II) are placed in 10 ml dioxane, first 3.6 ml diisopropylethylamine, then 1 g of 1-aminocyclopropanemethanol (see 8.2) are added. The reaction mixture is heated to 160° C. until no further reaction takes place, then cooled and evaporated down. The residue is treated with cyclohexane/ethyl acetate (8:2) in the ultrasound bath and the solid is suction filtered and dried. 1.24 g (III-4) are obtained as a solid.

1. temperaturecooled
2. customevaporated down
3. additionThe residue is treated with cyclohexane/ethyl acetate (8:2) in the ultrasound bath
4. filtrationfiltered
5. customdried
6. custom1.24 g (III-4) are obtained as a solid