反应详情

温度

130 °C

0.27 g (II) are placed in 3 ml dioxane, then 0.45 ml diisopropylethylamine and 0.25 g (S)-5-amino-1-methylpiperidin-2-one are added. The reaction mixture is heated to 130° C. until no further reaction takes place, then cooled and evaporated down. The product is extracted with dichloromethane and purified by chromatography (preparative HPLC, method B). 0.26 g (III-5) are obtained as a solid. Analytical HPLC-MS (method A): RT=1.06 min.

1. temperaturecooled
2. customevaporated down
3. extractionThe product is extracted with dichloromethane
4. custompurified by chromatography (preparative HPLC, method B)
5. custom0.26 g (III-5) are obtained as a solid