反应详情

Ethyl 2-azido-3-(5-methylthiophen-2-yl)acrylate (3.38 g) was dissolved in m-xylene (30 mL) and the mixture was heated at reflux for 1 hour. The reaction solution was concentrated under reduced pressure. To the residue was added n-hexane and the residue was washed with n-hexane. The solid was collected by filtration, and dried under reduced pressure to give the title compound (2.56 g).

1. temperaturethe mixture was heated
2. temperatureat reflux for 1 hour
3. concentrationThe reaction solution was concentrated under reduced pressure
4. additionTo the residue was added n-hexane
5. washthe residue was washed with n-hexane
6. filtrationThe solid was collected by filtration
7. customdried under reduced pressure