Water → 1'-Benzyl-6-bromo-4-hydroxy-spiro[chromane-2,4'-piperidine]

関与物質

役割	名称	HCID	仕込み量
反応物	Water	HCID 962	—
反応物	Sodium borohydride	HCID 4311764	—
反応物	1'-Benzyl-6-bromospiro[chroman-2,4'-piperidin]-4-one	HCID 12887955	—
溶媒	Methanol	HCID 887	—
生成物	1'-Benzyl-6-bromo-4-hydroxy-spiro[chromane-2,4'-piperidine]	HCID 52952196	99.1%

反応手順

A mixture of 1′-benzyl-6-bromo-spiro[chromane-2,4′-piperidine]-4-one (3.0 g, 7.8 mmol) and NaBH4 (1.47 g, 38.75 mmol) in MeOH (20 ml) was stirred at RT. After 3 h, the solution was poured into water and the product was extracted with DCM (50 ml). The organic phase was dried over Na2SO4, filtered and evaporated under vacuum to give 1′-benzyl-6-bromo-4-hydroxy-spiro[chromane-2,4′-piperidine] (3.0 g) as a light yellow solid.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US09115148B2
出典データセット	uspto-grants-2015_08
ORD ID	ord-afd1b3c9b1cd4c1d8e925b055f3fc7e5
出典メモ	uspto-grants-2015_08