Potassium Carbonate → HCID 18710218, compound

HRID 51831Notes

Reaction equation

HRID 51831 reaction equation
[CH:1]([C:4]1[CH:5]=[C:6]([C:16]#[C:17][Si](C)(C)C)[CH:7]=[CH:8][C:9]=1[CH2:10][O:11][C:12]1([CH3:15])[CH2:14][CH2:13]1)([CH3:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+]>CO>[C:16]([C:6]1[CH:7]=[CH:8][C:9]([CH2:10][O:11][C:12]2([CH3:15])[CH2:13][CH2:14]2)=[C:4]([CH:1]([CH3:3])[CH3:2])[CH:5]=1)#[CH:17]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 69548710[3-Isopropyl-4-(1-methyl-cyclopropoxymethyl)-phenylethynyl]-trimethylsilane2×

Product 1

HCID 18710218HCID 18710218, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Using General Procedure E; [3-isopropyl-4-(1-methyl-cyclopropoxymethyl)-phenylethynyl]-trimethylsilane (Intermediate 165, 110.0 mg, 0.37 mmol) in methanol (6 mL) was treated with potassium carbonate (80.0 mg, 0.58 mmol) and stirred overnight at ambient temperature. The crude alkyne (84 mg, 100%) was used directly in the next reaction.

Sources & evidence

ORD record
ord-5defe226104749faa0df6f7c0c438da6
Source dataset
uspto-grants-2004_03
Patent number
US06713647B2

Reaction notes

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