反应详情

To a stirred solution of 5.00 g (17.7 mmol) (4-methoxy-7-nitro-benzothiazol-2-yl)-carbamic acid methyl ester in 140 ml methanol and 140 ml dichloromethane was added 1.5 g platinum (IV) oxide and the mixture was then stirred for 16 hours at room temperature under an atmosphere of hydrogen. The mixture was then filtered and the filtrate concentrated in vacuo to afford 4.03 g (90%) (7-amino-4-methoxy-benzothiazol-2-yl)-carbamic acid methyl ester as a grey crystalline solid. ES-MS m/e (%):276 (M+Na+, 28), 254 (M+H+, 100).

1. filtrationThe mixture was then filtered
2. concentrationthe filtrate concentrated in vacuo