Hydrochloric Acid → HCID 118021890, compound

HRID 518583Notes

Reaction equation

HRID 518583 reaction equation
[ClH:1].[C:2]1([NH:11]C(=O)OC(C)(C)C)[C:7]2[CH2:8][CH2:9][CH2:10][C:6]=2[CH:5]=[CH:4][N:3]=1>C(Cl)Cl>[ClH:1].[C:2]1([NH2:11])[C:7]2[CH2:8][CH2:9][CH2:10][C:6]=2[CH:5]=[CH:4][N:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 118022810HCID 118022810, compound

Product 1

HCID 118021890HCID 118021890, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

Anhydrous 1M HCl in DCM (20 mL) was added slowly to the title compound of step 3 (570 mg, 2.43 mmol) in DCM (10 mL) at 0° C. After stirring at rt for 1.5 h, evaporation of the volatile components gave the title compound (400 mg, 96%) as a white solid. 1H NMR (CD3OD, 300 MHz): δ 7.66 (d, J=6.6 Hz, 1H), 6.88 (d, J=6.6 Hz, 1H), 3.04 (t, J=7.8, 7.2 Hz, 2H), 2.86 (t, J=7.8, 7.2 Hz, 2H), 2.17-2.27 (m, 2H). LCMS: 135 (M+1)+

Workup

  1. customevaporation of the volatile components

Sources & evidence

ORD record
ord-a7a69ab0e4824e5c92ed739dcd7fc837
Source dataset
uspto-grants-2015_08
Patent number
US09115114B2

Reaction notes

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