Hydrochloric Acid → HCID 178479761, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of cis-methyl 4-(2-chloro-5-nitropyridin-4-ylamino)cyclohexanecarboxylate (2.51 g, 8.00 mmol) in dioxane (10 mL) was added 4N aqueous HCl (52.0 mL, 208 mmol), and the resulting mixture was stirred at 60° C. for 3 hours. The mixture was concentrated to dryness to afford cis-4-(2-chloro-5-nitropyridin-4-ylamino)cyclohexanecarboxylic acid hydrochloride as a yellow solid (2.69 g, 100% yield). MS m/z=300.2 [M+H]. Calc'd for C12H14ClN3O4: 299.1.

Provenance & Evidence