HRID518619
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
CONDITIONS
反应条件
- 温度
- 60 °C
PROCEDURE
实验过程
To a suspension of cis-methyl 4-(2-chloro-5-nitropyridin-4-ylamino)cyclohexanecarboxylate (2.51 g, 8.00 mmol) in dioxane (10 mL) was added 4N aqueous HCl (52.0 mL, 208 mmol), and the resulting mixture was stirred at 60° C. for 3 hours. The mixture was concentrated to dryness to afford cis-4-(2-chloro-5-nitropyridin-4-ylamino)cyclohexanecarboxylic acid hydrochloride as a yellow solid (2.69 g, 100% yield). MS m/z=300.2 [M+H]. Calc'd for C12H14ClN3O4: 299.1.
WORKUP
后处理
- concentrationThe mixture was concentrated to dryness