2-Propanesulfonyl chloride → HCID 178477703, compound

HRID 518627Notes

Reaction equation

HRID 518627 reaction equation
[N:1]1([CH2:7][CH2:8][O:9][C:10]2[N:15]=[CH:14][C:13]3[NH:16]/[C:17](=[N:25]\[C:26](=[O:33])[C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=4)/[N:18]([CH:19]4[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]4)[C:12]=3[CH:11]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:34][CH:35]([S:37](Cl)(=[O:39])=[O:38])[CH3:36]>>[CH:35]([S:37]([N:22]1[CH2:21][CH2:20][CH:19]([N:18]2[C:12]3[CH:11]=[C:10]([O:9][CH2:8][CH2:7][N:1]4[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]4)[N:15]=[CH:14][C:13]=3[NH:16]/[C:17]/2=[N:25]\[C:26](=[O:33])[C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH2:24][CH2:23]1)(=[O:39])=[O:38])([CH3:36])[CH3:34].[CH2:35]([S:37]([N:22]1[CH2:21][CH2:20][CH:19]([N:18]2[C:12]3[CH:11]=[C:10]([O:9][CH2:8][CH2:7][N:1]4[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]4)[N:15]=[CH:14][C:13]=3[NH:16]/[C:17]/2=[N:25]\[C:26](=[O:33])[C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH2:24][CH2:23]1)(=[O:39])=[O:38])[CH3:34]

Participants

4

Reactant 2

HCID 824082-Propanesulfonyl chlorideHCID 178522618HCID 178522618, compound

Product 2

HCID 178461040HCID 178461040, compoundHCID 178477703HCID 178477703, compoundYield 19%

Procedure

The title compound was prepared from (E)-N-(6-(2-(piperidin-1-yl)ethoxy)-1-(piperidin-4-yl)-1H-imidazo[4,5-c]pyridin-2(3H)-ylidene)benzamide and 2-propanesulphonyl chloride using a method analogous to the preparation of (E)-N-(1-(1-(ethylsulfonyl)piperidin-4-yl)-6-(2-(piperidin-1-yl)ethoxy)-1H-imidazo[4,5-c]pyridin-2(3H)-ylidene)benzamide (20 mg, 19.0% yield). MS m/z=555.2 [M+H]. Calc'd for C28H38N6O4S: 554.3

Sources & evidence

ORD record
ord-0c06cf1511554eb3b84ac430ca26fcbc
Source dataset
uspto-grants-2015_08
Patent number
US09115127B2

Reaction notes

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