反应详情

温度

80 °C

A mixture of 2-fluoro-4-(4-methoxybenzyloxy)-1-nitrobenzene (507 mg, 1.82 mmol), cis-4-amino-N-isopropylcyclohexanecarboxamide hydrochloride (404 mg, 1.82 mmol), DIPEA (0.70 mL, 4.02 mmol) and ACN (3.6 mL) were placed in a sealed tube, and the tube was heated at 80° C. for 6 hours. The mixture was allowed to cool and evaporated. The residue was diluted with DCM (15 mL), washed with water (×2), and then washed with brine. The organic layer was dried over Na2SO4. The mixture was purified via flash chromatography using a linear gradient of 0% to 10% MeOH in DCM. The title compound was collected as a yellow solid (476 mg, 59% yield).

1. customwere placed in a sealed tube
2. temperatureto cool
3. customevaporated
4. additionThe residue was diluted with DCM (15 mL)
5. washwashed with water (×2)
6. washwashed with brine
7. dry with materialThe organic layer was dried over Na2SO4
8. customThe mixture was purified via flash chromatography