反应详情

温度

100 °C

To solution of cis-N-isopropyl-4-(2-methoxy-5-nitropyridin-4-ylamino)cyclohexanecarboxamide (264 mg, 0.785 mmol) in AcOH (1.5 μmL) was added iron powder (219 mg, 3.92 mmol), and the mixture was heated to 100° C. for 5 minutes. The mixture was allowed to cool to RT, was diluted with 10% MeOH/DCM, and was filtered through a pad of Celite® brand filter aid and concentrated. The mixture was purified via flash chromatography using a linear gradient of 0% to 10% of 1% NH4OH in MeOH in DCM. Cis-4-(5-amino-2-methoxypyridin-4-ylamino)-N-isopropylcyclohexanecarboxamide was isolated as a red film (211 mg).

1. temperatureto cool to RT
2. filtrationwas filtered through a pad of Celite® brand
3. filtrationfilter aid
4. concentrationconcentrated
5. customThe mixture was purified via flash chromatography