反应详情

To a solution of tert-butyl 2-(4-((E)-2-(4-fluorobenzoylimino)-1-(cis-4-(isopropylcarbamoyl)cyclohexyl)-2,3-dihydro-1H-imidazo[4,5-c]pyridin-6-yloxy)piperidin-1-yl)acetate (81 mg, 0.127 mmol) in dioxane (1.2 mL) was added HCl (4N dioxane) (0.127 mL, 0.509 mmol) and 2 drops of concentrated HCl (0.010 mL, 0.127 mmol). The resulting mixture was stirred at RT for 4 hours. The reaction mixture was concentrated and triturated with about 2 mL of dioxane to produce a precipitate. The off-white solid was collected to afford the title compound (70 mg, 89% yield). M/Z calc'd for C30H37FN6O5: 580.28. found 581 [M+H].

1. concentrationThe reaction mixture was concentrated
2. customtriturated with about 2 mL of dioxane
3. customto produce a precipitate
4. customThe off-white solid was collected