4-Piperidinol, 1-methyl- → HCID 178457851, compound

HRID 518706Notes

Reaction equation

HRID 518706 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([OH:8])[CH2:4][CH2:3]1.Cl[C:10]1[CH:15]=[C:14]([NH:16][C@@H:17]2[CH2:22][CH2:21][C@H:20]([C:23]([NH:25][CH:26]([CH3:28])[CH3:27])=[O:24])[CH2:19][CH2:18]2)[C:13]([N+:29]([O-:31])=[O:30])=[CH:12][N:11]=1>>[CH:26]([NH:25][C:23]([C@H:20]1[CH2:19][CH2:18][C@@H:17]([NH:16][C:14]2[C:13]([N+:29]([O-:31])=[O:30])=[CH:12][N:11]=[C:10]([O:8][CH:5]3[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3][CH2:4]3)[CH:15]=2)[CH2:22][CH2:21]1)=[O:24])([CH3:28])[CH3:27]

Participants

3

Reactant 2

HCID 660484-Piperidinol, 1-methyl-HCID 178457831HCID 178457831, compound

Product 1

HCID 178457851HCID 178457851, compound

Procedure

Intermediate cis-N-isopropyl-4-(2-(1-methylpiperidin-4-yloxy)-5-nitropyridin-4-ylamino)cyclohexanecarboxamide was prepared from 1-methylpiperidin-4-ol using a procedure analogous to that used for cis-4-(2-chloro-5-nitropyridin-4-ylamino)-N-isopropylcyclohexanecarboxamide (95 mg).

Sources & evidence

ORD record
ord-593b1d85c4cc416eaaa39578202e3c20
Source dataset
uspto-grants-2015_08
Patent number
US09115127B2

Reaction notes

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