反应详情

To a solution of tert-butyl cis-4-(isopropylcarbamoyl)cyclohexylcarbamate (39.11 g, 138 mmol) in DCM (400 mL) was added 4 M HCl in dioxane (138 mL, 550 mmol), and 0.5 mL concentrated HCl. The reaction was stirred vigorously overnight at RT. A large amount of white precipitate had formed in the flask and it was collected by vacuum filtration, washed with DCM, and dried in vacuo, to generate cis-4-amino-N-isopropylcyclohexanecarboxamide hydrochloride as a white powder (31.08 g, 102% yield).

1. customA large amount of white precipitate had formed in the flask and it
2. filtrationwas collected by vacuum filtration
3. washwashed with DCM
4. customdried in vacuo