1,4-Dioxane hydrochloride → HCID 66728677, compound

Participants

Reaction Steps

To a solution of benzyl 4-(2-hydroxy-2-methylpropyl)piperazine-1-carboxylate (0.54 g, 1.847 mmol) in EtOH (10 mL) was added 10% palladium on carbon (0.1 g, 0.094 mmol). The reaction was stirred overnight under a hydrogen atmosphere. After 16 hours, the reaction was filtered through Celite® brand filter aid (rinsed with MeOH and DCM). The filtrate was concentrated to a clear oil, the oil was diluted with EtOAc, and 4 N HCl/dioxane (0.5 mL; 2 mmol) was added dropwise. The white precipitate was collected by vacuum filtration, washed with diethyl ether, and dried in vacuo, to generate 2-methyl-1-(piperazin-1-yl)propan-2-ol hydrochloride as a brown powder (0.31 g, 86% yield).

Provenance & Evidence