Hydrochloric Acid → HCID 66728668, compound

HRID 518722Notes

Reaction equation

HRID 518722 reaction equation
[F:1][C:2]([F:20])([F:19])[CH2:3][NH:4][CH2:5][CH:6]1[CH2:11][CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8][CH2:7]1.[ClH:21].O1CCOCC1>C(Cl)Cl>[ClH:21].[ClH:21].[F:20][C:2]([F:1])([F:19])[CH2:3][NH:4][CH2:5][CH:6]1[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 667286651-Piperidinecarboxylic acid, 4-[[(2,2,2-trifluoroethyl)amino]methyl]-, 1,1-dimethylethyl ester

Product 1

HCID 66728668HCID 66728668, compoundYield 79%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of tert-butyl 4-((2,2,2-trifluoroethylamino)methyl)piperidine-1-carboxylate (1.49 g, 5.03 mmol) in DCM (25 mL) was added 4 N HCl in dioxane (5.03 mL, 20.11 mmol). The reaction was stirred at RT. After 16 hours, the white precipitate was collected by vacuum filtration, washed with diethyl ether, and dried in vacuo, to generate 2,2,2-trifluoro-N-(piperidin-4-ylmethyl)ethanamine dihydrochloride as a white powder (1.07 g, 3.98 mmol, 79% yield).

Workup

  1. filtrationthe white precipitate was collected by vacuum filtration
  2. washwashed with diethyl ether
  3. customdried in vacuo

Sources & evidence

ORD record
ord-5fe878d7a94946e99177089a9847a72f
Source dataset
uspto-grants-2015_08
Patent number
US09115127B2

Reaction notes

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