反应详情

To a stirred solution of 120 mg (0.57 mmol) 4-methoxy-N7-methyl-benzothiazole-2,7-diamine in 1 ml dichloromethane and 1 ml tetrahydrofuran at 0° C. was added 0.09 ml (1.15 mmol) pyridine. A solution of 0.04 ml (0.57 mmol) acetyl chloride in 1 ml dichloromethane was then added dropwise and stirring continued for 3 h at 0° C. The mixture was then concentrated in vacuo. Flash chromatography (30/1 dichloromethane/methanol) afforded 60 mg (42%) N-(2-amino-4-methoxy-benzothiazol-7-yl)-N-methyl-acetamide as a light brown crystalline solid, ES-MS m/e (%): 252 (M+H+, 100).

1. concentrationThe mixture was then concentrated in vacuo