Benzyl Bromide → HCID 22737001, 화합물

HRID 51880노트

반응식

HRID 51880 반응식
[CH2:1]([NH:3][C:4]1[C:12]2[S:11][C:10]([NH2:13])=[N:9][C:8]=2[C:7]([O:14][CH3:15])=[CH:6][CH:5]=1)[CH3:2].C(=O)([O-])[O-].[K+].[K+].[CH2:22](Br)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1.[F:30][C:31]1[CH:39]=[CH:38][C:34]([C:35](O)=[O:36])=[CH:33][CH:32]=1.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.C(N(C(C)C)C(C)C)C>CN(C=O)C.C1COCC1>[CH2:22]([N:3]([CH2:1][CH3:2])[C:4]1[C:12]2[S:11][C:10]([NH:13][C:35](=[O:36])[C:34]3[CH:38]=[CH:39][C:31]([F:30])=[CH:32][CH:33]=3)=[N:9][C:8]=2[C:7]([O:14][CH3:15])=[CH:6][CH:5]=1)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

참가 물질

9

반응물 6

HCID 7498Benzyl BromideHCID 99734-Fluorobenzoic AcidHCID 11430Potassium CarbonateHCID 81531DiisopropylethylamineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 22737006N7-ethyl-4-methoxy-benzothiazole-2,7-diamine

생성물 1

HCID 22737001HCID 22737001, 화합물

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 8028Tetrahydrofuran용매

실험 절차

From N7-ethyl-4-methoxy-benzothiazole-2,7-diamine with potassium carbonate and benzyl bromide in DMF, then treatment with 4-fluorobenzoic acid, HATU and N-ethyldiisopropylamine in THF. ES-MS m/e (%): 436 (M+H+, 100).

출처 및 근거

ORD 기록
ord-93cee7089f0c4f568df496a07b7521cf
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06713499B2

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