Ammonium formate → HCID 86698003, compound

HRID 518842Notes

Reaction equation

C([O-])=O.[NH4+].[CH3:5][N:6]1[C:12]2[CH:13]=[CH:14][C:15]([N+:21]([O-])=O)=[C:16]([O:17][CH:18]([CH3:20])[CH3:19])[C:11]=2[CH2:10][CH2:9][CH2:8][C:7]1=[O:24]>CO.[Pd]>[NH2:21][C:15]1[CH:14]=[CH:13][C:12]2[N:6]([CH3:5])[C:7](=[O:24])[CH2:8][CH2:9][CH2:10][C:11]=2[C:16]=1[O:17][CH:18]([CH3:20])[CH3:19]

Participants

Conditions

Temperature: 80 °C

Procedure

567 mg of ammonium formate and 478 mg of Pd/C (10%) are added to a solution of 416 mg of 1-methyl-7-nitro-6-(propan-2-yloxy)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one in 30 ml of methanol. The reaction medium is microwave-heated at 80° C. for 5 minutes. The mixture is filtered on Clarcel, and the Clarcel is rinsed with methanol. The filtrate is concentrated under reduced pressure, so as to give 380 mg of 7-amino-1-methyl-6-(propan-2-yloxy)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one in the form of a colourless gum.

Workup

filtrationThe mixture is filtered on Clarcel
washthe Clarcel is rinsed with methanol
concentrationThe filtrate is concentrated under reduced pressure

Sources & evidence

ORD record: ord-a070fb98f5234e9e92f14e8a20f11485
Source dataset: uspto-grants-2015_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09115140B2

Reaction notes

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