Water → 4-Bromo-1,5-dimethyl-1H-pyrrole-2-carbonitrile

HRID 518927Notes

Reaction equation

HRID 518927 reaction equation
[Br:1]Br.[CH3:3][N:4]1[C:8]([CH3:9])=[CH:7][CH:6]=[C:5]1[C:10]#[N:11].O>C(O)(=O)C>[Br:1][C:7]1[CH:6]=[C:5]([C:10]#[N:11])[N:4]([CH3:3])[C:8]=1[CH3:9]

Participants

5

Reactant 3

HCID 962WaterHCID 24408BromineHCID 918121,5-Dimethylpyrrole-2-carbonitrile

Product 1

HCID 153965834-Bromo-1,5-dimethyl-1H-pyrrole-2-carbonitrile

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent2×

Procedure

A solution of bromine (6.58 mL, 0.13 mol) in acetic acid (60 mL) is added dropwise, with the aid of a dropping funnel, to a solution of 1,5-dimethyl-1H-pyrrole-2-carbonitrile (15.0 g, 0.12 mol) in acetic acid (300 mL). The batch is stirred at ambient temperature for 24 hours. The reaction mixture is then poured into a beaker containing 300 mL of water.

Workup

  1. additionThe reaction mixture is then poured into a beaker

Sources & evidence

ORD record
ord-b593c36de88645c58631da8ce0735ef7
Source dataset
uspto-grants-2015_08
Patent number
US09115159B2

Reaction notes

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