HCID 131733362, compound → HCID 131733364, compound

HRID 518932Notes

Reaction equation

HRID 518932 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[N:23]3[C:18]([CH2:19][CH2:20][CH2:21][CH2:22]3)=[C:17]([C:24]([N:26]([C:37]3[CH:42]=[CH:41][C:40]([O:43][Si:44]([C:47]([CH3:50])([CH3:49])[CH3:48])([CH3:46])[CH3:45])=[CH:39][CH:38]=3)[C:27]3[CH:28]=[C:29]4[CH:35]=[CH:34][N:33]([CH3:36])[C:30]4=[N:31][CH:32]=3)=[O:25])[CH:16]=2)=[C:11]([C:51]([N:53]2[C@H:62]([CH2:63][N:64]3[CH2:69][CH2:68][O:67][CH2:66][CH2:65]3)[CH2:61][C:60]3[C:55](=[CH:56][CH:57]=[CH:58][CH:59]=3)[CH2:54]2)=[O:52])[CH:10]=1)C1C=CC=CC=1>C(O)C.[Pd]>[Si:44]([O:43][C:40]1[CH:41]=[CH:42][C:37]([N:26]([C:27]2[CH:28]=[C:29]3[CH:35]=[CH:34][N:33]([CH3:36])[C:30]3=[N:31][CH:32]=2)[C:24]([C:17]2[CH:16]=[C:15]([C:12]3[CH:13]=[CH:14][C:9]([OH:8])=[CH:10][C:11]=3[C:51]([N:53]3[C@H:62]([CH2:63][N:64]4[CH2:65][CH2:66][O:67][CH2:68][CH2:69]4)[CH2:61][C:60]4[C:55](=[CH:56][CH:57]=[CH:58][CH:59]=4)[CH2:54]3)=[O:52])[N:23]3[C:18]=2[CH2:19][CH2:20][CH2:21][CH2:22]3)=[O:25])=[CH:38][CH:39]=1)([C:47]([CH3:50])([CH3:49])[CH3:48])([CH3:46])[CH3:45]

Participants

4

Reactant 1

HCID 131733362HCID 131733362, compound

Product 1

HCID 131733364HCID 131733364, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

0.9 g of Pd/C 10% is added to a solution, in 100 mL of ethanol, of 8.88 g (8.4 mmol) of the compound obtained in Step C, whilst bubbling through argon. The reaction mixture is placed under 1.2 bars of hydrogen at ambient temperature for 15 hours. The catalyst is filtered off and the solvent is evaporated off under reduced pressure to provide the title compound.

Workup

  1. customwhilst bubbling through argon
  2. filtrationThe catalyst is filtered off
  3. customthe solvent is evaporated off under reduced pressure

Sources & evidence

ORD record
ord-0d642f3fd6094065a81fab69f67bef1f
Source dataset
uspto-grants-2015_08
Patent number
US09115159B2

Reaction notes

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